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Thus, although GIPR in the AP is required for the weight loss effects of GIPR agonists, it is not the target of therapeutic GIPR antagonists, supporting recent findings that Gipr KO in GABAergic neurons also abolished responses to GIPR agonism but not antagonism 6

Strength training or weightlifting can also help prevent muscle loss

The decision to continue, reduce, or stop semaglutide should be made with your healthcare provider based on symptom severity, the benefit you are receiving from the medication, and alternative management options

N Engl J Med 389(6):514526 Drucker DJ (2025) Discovery of GLP-1-Based Drugs for the Treatment of Obesity

Naltrexone (Revia) as monotherapy or in combination with any medication may interfere with acute pain management and perioperative treatment that requires opioids