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Treatment of Otsuka Long Evans Tokushima Fatty (OLETF) rats, an obese animal model of type 2 diabetes, with the PPAR agonist fenofibrate reduced the decline in beta cell mass and prevented the development of diabetes [23]

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Most evidence currently derives from rodent models and small observational cohorts, meaning larger randomized trials are essential before GLP-1 medications can be recommended as primary addiction treatments

Tirzepatide, available under the brand names Zepbound and Mounjaro, is a prescription medication approved for weight management

Human GLP-2R protein colocalizes to 5-HT-containing cells in the epithelium, a neurotransmitter released by enteroendocrine cells (Guan et al., 2006)

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