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Paradoxine drives thermogenesis through TRPV1 receptor activation and brown adipose tissue (BAT) stimulation a separate heat-generating mechanism that operates through adrenergic and uncoupling protein pathways independent of carnitine

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Furthermore, the activation of GLP-1R signaling in the ventromedial hypothalamus (VMH) can also control energy expenditure by promoting food intake-independent weight loss by inducing brown adipose tissue (BAT) thermogenesis and browning through a sympathetic drive to BAT [6]

A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in France, as Part of Local Clinical Practice (SURE FRANCE)