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The dual mechanism is responsible for the higher average weight loss observed in clinical trials

It belongs to a class of drugs called GLP-1 receptor agonists (GLP-1 RAs), which work by mimicking the action of a hormone called GLP-1

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Recognition that active GPCRs can continue to generate cAMP signals from endosomal compartments (Calebiro et al., 2009) has led to increased interest in GPCR trafficking, including for the GLP1 receptor