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They're not necessarily indicators of intolerance but rather evidence of pharmacological activity

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Then, the rats started to drink excessively, then to eat and repeatedly drink water for a period of a few minutes after which they regained normal behavior, drank and then ate and showed no behavioral abnormalities until their sacrifice ( Table 6 )

doi:10.5301/jn.5000077

Based on the factors mentioned above, it is evident that the position, property, conformation, number, and other factors of the staple all have a significant impact on the binding affinity to target PPIs

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