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This question is becoming increasingly relevant as clinicians observe patients benefiting from GLP-1 therapy even without significant weight loss

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doi: 10.3389/fphar.2025.1704083 Received 12 September 2025 Revised 16 December 2025 Accepted 18 December 2025 Published 21 January 2026 Volume 16 - 2025 Edited by Chen Ling, Fudan University, China Reviewed by Wentao Jia, Changhai Hospital, China Jie Cheng, Jiangsu University of Science and Technology, China Updates Copyright 2026 Li, Zhang, Li and Zheng