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dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies
The blood sugar effect of peptides is typically not a concern for non-diabetics, but in this case, the individual experienced severe gastrointestinal effects, highlighting the importance of caution when using these drugs 1m6s
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Trayhurn P, Beattie JH
Copper peptides are generally well tolerated
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