Consensus sequence One approach that has been taken is to design vaccine antigens that are enriched for conserved T and B-cell epitopes either as a consensus sequence (which is the closest natural circulating sequence to a bioinformatically calculated consensus) or as a string of epitopes taken out of their natural context within the viral protein (Fig
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A neuroimmune panel that evaluates immune reactivity to brain, myelin, peripheral nerve, and bloodbrain barrier antigens, helping clarify contributors to complex neurological symptoms
Consequences of ACE2 hijack The viral hijack of hACE2 could compromise patients health for extended periods of time, especially among COVID-19 and PASC with comorbidities (i.e., CVD, T2DM, brain and kidney dysfunctions) 300,304
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However, the structural polymorphism of A, including monomers, soluble oligomers, protofibrils, and amyloid plaques, along with numerous pathogenic variants, complicates the selection of precise targets and adds to the complexity of designing effective drugs
