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This gradual progression is one reason vitamin B12 deficiency is often missed. By the time injections are recommended, the body usually needs a more direct and reliable way to restore levels

MTHFR mutations involve changes in the methylenetetrahydrofolate reductase gene, influencing how the body processes key nutrients like folate (vitamin B9)

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PMID 29184729 Baxter N, et al

Before you take folate supplements for MS, its also important that a doctor checks your vitamin B12 levels with a blood test