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Semaglutide is a GLP-1 receptor agonist that works on the pancreas, brain, and gastrointestinal tract, not the biliary system directly

The evidence provided in these papers is stronger for dopamine-related reward modulation than for direct serotonin-mediated mood effects

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Dieting didnt help, and I was frustrated

The SURMOUNT-4 trial demonstrated that following 36 weeks of tirzepatide (producing 21.1% weight loss), continuing medication yielded an additional 5.5% reduction, while switching to placebo resulted in 14% weight regain