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JAMA Surgery study of 1,046 patients identified independent risk factors for food retention with GLP-1 RA use (odds ratio 9.19, 95% confidence interval 2.7330.8), with tirzepatide demonstrating the strongest association amongst available agents [33]

Observational studies have suggested that weight reduction can improve lymphedema symptoms and reduce limb volume in obese patients with the condition, though the quality of evidence remains limited