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(146) observed significant blood-to-brain influx for non-acylated GLP-1 mimetics like exendin-4 and lixisenatide, whereas acylated GLP-1 analogues such as liraglutide and semaglutide showed minimal blood-brain barrier penetration in mice

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But when done correctly, sublingual administration offers a needle-free alternative that many people prefer, and the results can be genuinely comparable when absorption is optimized

Furthermore, GLP-1 receptor agonists allow greater treatment customization based on individual patient's disease progression and therapeutic response

In the trials, individuals with diabetes lost less weight with these medications than those without diabetes