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Furthermore, IGF-1 inhibited synaptic transmission by increasing the frequency of sIPSCs in response to A- reduction in sIPSC frequency [70]

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Glutamines role in cellular functions makes GLS inhibition an ideal candidate for combination therapy

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40,43,44,45 Furthermore, glutamine and cysteine metabolism are deeply linked, 46,47 because serine and glycine can derive from glutamine and, by entering the one-carbon metabolism pathway, they will contribute to homocysteine and cysteine syntheses