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Theoretical concerns Copper accumulation: GHK-CU contains copper, raising theoretical concerns about accumulation with long-term use

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About 60% of the total amount of B12 in the body is stored in the liver and 30% is stored in the muscles (4)

Inhibiting an endogenous metabolic enzyme can create effects beyond the intended experimental target, particularly when human exposure and long-term safety have not been established

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However, the mechanism behind the protective effects of metformin on OA remains incompletely understood, with modulation of oxidative stress emerging as a likely key contributor to its pharmacological action