Upstream open reading frames as regulators of mRNA translation
All doses of Novo Nordisks blockbuster diabetes and obesity treatments are listed as available on the Food and Drug Administrations drug shortage list as of Wednesday, raising the possibility that the medications could soon be taken off the list entirely, a development that could affect compounding pharmacies and patients relying on compounded drugs
Notable developments include identification of HLA-B35:01 genetic susceptibility for hepatotoxicity (241), establishment of regulatory limits based on pharmacogenetic data, and documentation of serious adverse drugnutrient interactions in vulnerable populations
Beyond monthly medication costs, Medicare-covered weight loss drugs often require specialist referrals and multiple office visits to address insurance requirements and dosing questions
Women using oral contraceptive pills should use an additional non-oral contraceptive method (such as barrier methods) for 4 weeks after starting tirzepatide and for 4 weeks after each dose increase, as delayed gastric emptying may reduce oral contraceptive absorption
Prion-like acceleration of a synucleinopathy in a transgenic mouse model
