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iGL cells were exposed to different mediums: iGL cells culture medium (Cell only), iGL culture medium supplemented with synthetic Exe4 peptide (Exe4 solution) and with scExe4 peptide secreted from Hepa1-6 and HeG2 cells transfected with the scExe4 expression plasmid (scExe4_Hepa1-6 and scExe4_HepG2, respectively)

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Altering the pharmacokinetic profile, even while maintaining the same total weekly dose, could theoretically affect receptor desensitization patterns, immune response to the peptide, or metabolic adaptation in ways that have not been characterized

[162] While there are no published studies on this subject, it does appear that the edema is dose dependent