GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes
On the other hand, KPV is a shorter peptide linked with anti-inflammatory properties
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Most strikingly, the SELECT trial demonstrated that semaglutide significantly reduced MACE in individuals without T2DM but with overweight or obesity and established CV risk (HR 0.80), making it the first GLP-1 RA approved for CV risk reduction in a non-diabetic population (32)