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Qualitative studies indicate that some individuals experience the pharmacological reduction of appetite and modulation of reward sensitivity as both relieving and unfamiliar or disorienting [77, 78]

In terms of side effect profile, yes

Van Kempen et al., 2001

For spinal structures with naturally limited blood supply (particularly the intervertebral discs, which are largely avascular), this enhanced circulation to surrounding tissues can make a meaningful difference in healing capacity