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Briefly, quantification of signal bias was performed using pharmacologically derived parameters of agonist affinity (Ka) and efficacy (tau) for each ligand in each of the three signalling pathways (cAMP accumulation, ERK1/2 phosphorylation, Intracellular Ca 2+ mobilisation)

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Selenoprotein P is primarily an extracellular antioxidant, exerting its protective effects by inhibiting the activity of peroxynitrite, a highly reactive oxidant