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Consistent with expression of Tie2-Cre within HL cells (23), we also observed reduction of Glp1r mRNA transcripts in jejunum and in purified small bowel IELs, the major GLP-1R + cell type within the small bowel

That accounts for roughly 60% of the reduction in energy expenditure following significant weight loss

Free Radic Biol Med 2009;47:469-84

doi: 10.1016/j.cdtm.2020.11.002 192 FenouilletEVigourouxASteinbergJGChagvardieffARetornazFGuieuRet al

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