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10.1007/s11427-023-2532-5 27 LiL.ZhaoY.DingY.GuoL.DaiR.ChenA.et al (2025)

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We also demonstrate metformin-mediated alterations to cell cycle distribution and progression following radiation in HCT116 and SW837 cells, with metformin demonstrated to reduce the proportion of G2/M phase cells and prevent radiation-induced G2/M blockade in these cells

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This is the most significant limitation No statistical significance testing: The paper does not report p-values or statistical tests