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Consistent with our findings, four cohort studies found no increased risk of suicidal ideation between GLP-1 RAs and SGLT-2 inhibitors [11, 12, 28, 29]

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Methods: Lipodystrophic insulin resistant and glucose intolerant seipin knockout mice were treated with the GLP-1R agonist liraglutide either acutely preceding analyses of insulin and glucose tolerance or chronically prior to metabolic phenotyping and ex vivo studies

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Tirzepatide 10 mg and 15 mg were also associated with lower fasting insulin levels compared to dulaglutide and placebo [74]