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Nausea may increase slightly as the dose doubles, but the B12 component and slow escalation help manage it

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Mood Changes Irritability, depression, anxiety, lack of motivation

The very high and constant levels of GLP-1 agonists that occurs after they are injected probably explains both their beneficial effects and their side effects, for example, activation of the part of the brain that makes us feel nauseous

Phase 1 and phase 2 studies of the clinical trial development program for AMG133 are completed with results from phase 1 publicly available (84), while, at this time, phase 2 data have only been disclosed through a company announcement with headline results (85)

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