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Browne CJ, Futamura R, Minier-Toribio A, Hicks EM, Ramakrishnan A, Martnez-Rivera FJ, et al

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Results Chronic semaglutide treatment improves glucose tolerance without altering growth of non-diabetic non-obese juvenile mice To determine the effects of chronic semaglutide treatment during the juvenile developmental window, we characterized glucose metabolism of animals fed an experimental diet meeting the nutritional requirements for optimal growth conditions (AIN-93G 29 , hereafter referred to as control diet, CD), and treated with either vehicle (Veh) or semaglutide (Sema)

High expression levels are found in the distal ileum and colon, pancreatic alpha and beta cells, and several regions of the central nervous system (CNS)