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A proper consultation should include: Skin type assessment Review of current skincare and medical history Patch testing if needed Use of sterile, medical-grade equipment Pre-treatment skin preparation and cleansing Skin should be properly prepped before microneedling to reduce surface bacteria and ensure optimal results

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2006;136(3 Suppl):821S-826S

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Since polyphenols can act as PAINS in biochemical assays (autofluorescence, redox cycling, aggregation, metal chelation), in-vitro hits without orthogonal validation were downgraded

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