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False-positive selections and contaminants were excluded through iterative rounds of heterogeneous classification using three references and four decoy classes generated from noise particles through ab initio reconstruction in cryoSPARC (v4.5.0), resulting in stacks of 877,231, 815,775, and 906,048 particles from each dataset

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[3] At the 12 mg dose, the mean weight reduction was about 17.5% at 24 weeks (the primary endpoint) rising to roughly 24.2% at 48 weeks , compared with about 2.1% for placebo