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Mechanism three (glutathione depletion) : Nervous system disease (substantia nigra GSH is reduced approximately 40 percent at diagnosis), diseases that affect memory, neurological development disorders, mental health issues, ME/CFS, multiple sclerosis, ALS, and multiple chemical sensitivity

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For mechanistic insight into impact on inflammatory processes and cardiometabolic risk factors of xanthine oxidase inhibitor urate-lowering therapy (ULT) titration to target, we performed a prospective study of gout serum metabolomes from a ULT trial

PMCID: PMC4583086.

Ortiz et al

Gen Hosp Psych 1993;15:284-9