The authors emphasized the limitations of their findings, again with no proof that the drugs caused the problems
Cardiorenal protection with the newer antidiabetic agents in patients with diabetes and chronic kidney disease: A scientific statement from the American Heart Association
as such, it does not usually cause low blood sugar on its own
however, the long-term safety profile remains undefined
For those who do not achieve glycemic targets with lifestyle therapy, metformin, and SGLT2i, or who cannot tolerate these agents, whether due to adverse events or because other restrictions apply, other medications are recommended
Re-freezing the same vial after partial use accelerates breakdown and drastically shortens shelf life