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doi: 10.1097/00041327-199403000-00011

Preclinical research shows that bitter compounds act through an extracellular odorant binding protein to inhibit sweet-responsive neurons and block the response to sweet taste, 9 making bitter herbs an important therapeutic tool in modifying dietary choices

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As mentioned above, tirzepatide hasnt been compared to the higher dose of semaglutide (Wegovy) now available