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In 3-KO mice, these reductions were absent, reinforcing the idea that 3-AR plays a necessary role in regulating the response of brown adipose tissue to these agents [2]

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This trial the highest dose of retatrutide (12 mg) led to 16.9% weight loss (vs 3.0% with placebo) at 36 weeks

However with adequate protein intake and strength training you can preserve this muscle mass which is important for long-term fitness, health and continued weight loss

Just a tip: make sure you drink plenty of water and add fiber to your diet gradually instead of all at once in order to avoid bloating or discomfort