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The significant burden of CKD and CVD in type 1 diabetes highlights the need to identify novel therapies with the potential for heart and kidney protection

Abbreviations AHR, Aryl Hydrocarbon Receptor

The abrupt cessation of GLP-1R agonists in individuals with metabolic disorders may lead to adverse effects, as seen in a case where a patient developed IIH after discontinuing duraglutide [29]

For example, individuals with normal body weight may still exhibit features of cardiometabolic disease, sometimes referred to as metabolically obese normal-weight individuals

No changes were observed in the normoinsulinemic group, whose AUC HIE did not change during the 24 weeks of treatment

10.1038/s41422-021-00506-9 273 ZhangS.LiuQ.ChangM.PanY.YahayaB