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Key Takeaways Phase 2 retatrutide reduced mean systolic blood pressure by approximately 7-8 mmHg at top doses over 48 weeks Diastolic blood pressure dropped by approximately 2-4 mmHg Placebo arm BP changes were minimal, so the active-versus-placebo gap is real and meaningful The effect tracks with weight loss, suggesting most of the benefit is downstream of weight reduction rather than a direct vascular drug effect Patients on antihypertensive medications often need dose reductions as weight loss progresses to avoid excessive BP drops Direct answer Yes

Genetic Factors That Influence Your Personal Weight Loss Rate The PlexusDx Precision Peptide Genetic Test analyzes GLP1R, GIPR, FTO (rs9939609), and MC4R (rs17782313) variants that relate to GLP-1 and related signaling pathways

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How Ozempic affects your digestive system The very mechanism that makes Ozempic effective controlling blood sugar and promoting weight loss can also cause digestive issues, including constipation and diarrhea

Cancer Res 52(17):4587-90, 1992