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Wernicke-Korsakoff syndrome despite no alcohol abuse: A summary of systematic reports

Inside tumors, lymphatic vessels are compressed (68, 81), possibly due to the solid stress exerted by growing cancer cells (44, 45, 55, 56, 68, 8286), but functional lymphatic vessels in the tumor periphery remain and can transport antigen and metastatic cancer cells

Indeed, it has been shown that the inhibition of both the lactate transporter MCT1 and the key enzyme at the basis of lipid biosynthesis, i.e., the ATP citrate lyase (ACLY), strongly reduce the intracellular levels of acetyl-CoA, bringing the authors to the suggestion that lactate produced by cancer-associated fibroblasts (CAFs) represents the main source of acetyl-CoA in lipid-reprogrammed prostate cancer cells

Hunt CD, Meacham SL