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The Food and Drug Administration (FDA) recommends people who have a personal or family history of medullary thyroid cancer (MTC) should not use Zepbound along with people with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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Because different GLP-1 agonists have different FDA-labeled indications, they may be used for different reasons, such as type 2 diabetes or weight loss