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Serum urate levels in women remain relatively stable overall until menopause, at which time serum urate rises in association with loss of the natural uricosuric effect of estrogen (i.e., loss of the promotion by estrogen of renal excretion of uric acid, which is likely mediated in large part by sex hormone effects on one or more major urate transporters)

(Postmenopausal osteoporotic rats, bone density, bone microstructure) Zhao Jing, Sun Jian

Aug 1998;3(4):262-70

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Numerous studies, particularly in rodents, indicate that suppression of the GH/IGF1 axis has multiple benefits in terms of aging