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Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy

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Increases nerve tissue regeneration capacity

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We hypothesized that heterozygous C- Glud1 +/ mice exposed to stress would exhibit deficits in capacities that require intact hippocampal and mPFC function, i.e., spatial rule acquisition, cognitive flexibility and social function, whereas Glud1 heterozygosity or stress exposure alone would not elicit behavioral abnormalities

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The transmission electron microscopy (TEM) observation demonstrated the presence of the membrane particles indicative of EVs in both l-EV and s-EV fractions, with or without heating or freezing treatments (Supplementary Fig

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