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Statistics from the phase 3 SURMOUNT study, which recruited over 5,000 adults globally, demonstrated a pronounced reduction in body weight in the tirzepatide-treated group compared to placebo (NCT04184622)

Several important limitations should be kept in mind

5B) effects on murine macrophages RAW264.7 upon antigen stimulation, TNF- and phosphorylated inhibitor of B (IB) decreased and histone deacetylase 2 increased [108]

These include: Exenatide (Byetta, Bydureon) One of the first GLP-1s, modest weight loss of 23%

Other potential effects include slowing down the digestion of food and increasing the feeling of fullness after eating, which may be associated with weight loss