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This limits exposure to the treatment site and reduces potential for systemic side effects

In addition, consistent with the findings reported elsewhere, we found DMF induces the activation of NRF2, and NRF2 targets such as those involved in cystine uptake (SLC7A11) and GSH biosynthesis (GCLM and GCLC, the mediator and catalytic subunits of GCL) (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 108.Pace B.S., Shartava A., Pack-Mabien A., Mulekar M., Ardia A., Goodman S.R

Translational Gap: High

Quality and purity can vary significantly between sources, making pharmaceutical-grade sourcing essential for clinical use