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We developed a confocal immunofluorescence assay to measure FAK and the FAT domain binding partner, paxillin, presence at FAs to assess whether lead peptide 2012 can effectively inhibit the FAT-paxillin PPI and delocalize FAK from FA complexes (Fig

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Insulin secretion in the low-glucose (2 mM) state was neither inhibited by H-89 and/or ESI-09 nor stimulated by 007-AM (Fig

A two-way ANOVA (with mixed-effects analysis) was performed for statistical analysis, * P = 0.0416, ** P = 0.0388