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This C-terminal phosphorylation then leads to internalization via an unknown mechanism
Esposito, Simplification of complex insulin therapy: a story of dogma and therapeutic resignation
The degree of receptor activation is typically reported as the peptide concentration required for a response to reach 50% of its maximal value, known as the half-maximal effective concentration (EC 50 )
Taken together, these in vivo data from multiple CRC models support our conclusion that inhibition of mitochondrial metabolism by metformin treatment can enhance the response of 5FU treatment by increasing tumour cell death and impeding tumour growth
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