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While the inositol isomers work at the cell membrane to ensure that insulin signals are heard and glucose is successfully transported indoors, alpha-lipoic acid works deep within the mitochondria to ensure that the imported glucose is efficiently burned for energy rather than stored as ectopic fat

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Nieuwdorp, M., Gilijamse, P

Mitogen-activated Protein Kinases in Innate Immunity

also, lipids and C-reactive protein levels increased by week 120, yet maintaining a significant difference with respect to patients on placebo 77