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The results of such studies are compiled in Table 3 and are discussed sequentially hereafter

Key Findings from the Clinical Trial The study, led by Christian Hendershot at USC's Institute for Addiction Science, showed that weekly injections of semaglutide compared to placebo: Reduced alcohol cravings significantly Decreased drinking quantity overall Lowered the frequency of heavy drinking days What makes these results particularly exciting is that the magnitude of semaglutide's effects appeared potentially greater than what is typically seen with existing FDA-approved medications for alcohol use disorder, even though the drug was only administered at the lowest clinical doses

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Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice