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We find that tig-2 , a ligand in TGF- signalling, activates downstream gonadal longevity pathways (e.g., DA signalling) from DTC (Fig

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doi: 10.1007/s11739-020-02597-5 5 TuttleKRBakrisGLBilousRWChiangJLde BoerIHGoldstein-FuchsJet al

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When fetal fibroblasts were treated with Epitalon over multiple passages, they were able to bypass the Hayflick limit, dividing beyond 44 passages, compared to just 34 in untreated controls [26]