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Different scenarios of LC and AC concentrations likely reflect distinct metabolic dysfunction in this population, which opens the door for new targeted therapeutic interventions or prognostic tests

44 Excessive ROS can inhibit IRS1 activation by activating inflammation-related protein kinase C, inhibitor kappa B kinase (IKK), c-Jun N-terminal kinase (JNK), and p38 MAPK, thereby aggravating IR, 45 creating a vicious cycle