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Microdosing tirzepatide is more complex than semaglutide because of the dual receptor engagement, but both GLP-1 and GIP respond well to sustained lower levels
There are a lot of factors that can influence your weight as well as your quality of life
There is a secondary mechanism too
CKD benefits were similar, with the FLOW trial (3,500 patients with T2D and chronic kidney disease), Semaglutide (1 mg weekly) reduced the risk of kidney failure events and death from kidney- or cardiovascular-related causes by 24% (HR 0.76
A: Do not stop on your own
In comparison, patients who used retatrutide (8 mg and 12 mg once weekly) lost 17.5% at 24 weeks and 24.2% of their body weight after 48 weeks in phase 2 clinical trials
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