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Endocannabinoids derived from omega-3 PUFAs serve as precursors to more potent bioactive compounds that operate via both cannabinoid-dependent and independent pathways, exerting anti-inflammatory, anti-proliferative, and mood-regulating effects (59, 79)
If a patient notices a rash, it may go away within a day or two
Severe abdominal pain, persistent vomiting, yellowing skin, fainting, or signs of an allergic reaction deserve urgent medical attention
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In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019
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