Severe Arthralgia Severe, disabling joint pain reported in patients receiving DPP-4 inhibitors
In 2019, ESC guidelines recommended the use of SGLT2 inhibitors or GLP-1 RAs as first-line drugs in CV patients at high or very high risk with T2DM who do not receive any glucose-lowering treatment and the addition to current glucose-lowering therapy of SGLT2 inhibitors or GLP-1 RAs in those patients regardless of glucose control (Figure 3),18
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However, these small molecules show rapid efficacy in acute models, but their effects are transient and require repeated dosing
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Its important to choose something that isnt very difficult to give up, ideally something being eaten automatically and without thought e.g., salty snacks, small candies