By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus
555 These vaccines were designed, manufactured, evaluated, and brought to market in an extremely short period compared with traditional vaccine development timelines, highlighting the unique advantages of mRNA vaccines, including high safety, simple design, broad target range, and ease of scaling up production
This raises the possibility that GLP-1s could influence the gut-immune axis, which is often disrupted in autoimmune diseases
The most apparent benefit is enhanced energy levels
Never reuse needles, as this introduces bacteria, dulls the needle (causing more pain), and risks cross-contamination
"A rare presentation of an ancient disease: scurvy presenting as orthostatic hypotension"