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Ice crystal formation during freezing damages peptide structure

The copper-bound form is what interacts with genes related to repair, antioxidant activity, and tissue integrity

Wei W, Li Y, Wang C, Gao S, Zhao Y, Yang Z, et al

colours**: Titanium dioxide, iron oxides and iron hydroxides, Ponceau 4 R***, quinoline yellow***, patent blue V***

Collectively, these results demonstrate that the cytoprotective effects observed in MAPKAPK2-overexpressing vitiligo melanocytes under oxidative stress conditions are specifically dependent on MAPKAPK2

For this application, NPs are required to show aqueous stability, high crystallinity and a narrow size distribution