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Glia-driven neuroinflammation and systemic inflammation in alzheimers disease

It is a peptide derived from a protective protein naturally found in the stomach

Compared to APOE3 and APOE2, APOE4-mediated pathways of A clearance are impaired, and APOE4 exhibits a higher affinity interaction with A, potentially driving a more severe A plaque burden, 119,121,123 making it one of the strongest genetic risk factors for AD

FOXO4-DRI FOXO4-DRI is a synthetic peptide designed to selectively disrupt the interaction between FOXO4 and p53, thereby promoting the clearance of senescent cells and supporting tissue rejuvenation

The CLO alone-treated group represented the same records as the negative control group, with regular alveolar duct (D) and alveoli (AL) composition (Figure 6E)

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